Drug therapy during pregnancy

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Drug Therapy in Pregnancy

Major birth defects affect 3 to 5% of all live births. Most are of unknown etiology, but 1 to 3% of these are thought to be due to pharmaceutical or environmental agents. A teratogen is any chemical, pharmacologic, environmental, or mechanical agent that can cause deviant or disruptive development of the conceptus. Included in this definition are functional impairment, growth restriction, and c...

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Antihypertensive drug therapy for mild to moderate hypertension during pregnancy.

BACKGROUND Mild to moderate hypertension during pregnancy is common. Antihypertensive drugs are often used in the belief that lowering blood pressure will prevent progression to more severe disease, and thereby improve outcome. OBJECTIVES To assess the effects of antihypertensive drug treatments for women with mild to moderate hypertension during pregnancy. SEARCH STRATEGY We searched the C...

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Anticoagulant Therapy during Pregnancy

Fourteen patients were treated with anticoagulants during 15 pregnancies. Eleven had venous thrombosis, three with pulmonary embolism; three had prosthetic heart valves; and one had mitral stenosis with pulmonary hypertension. AU 15 were treated with heparin and 10 with warfarin. The mean duration of heparin therapy was 4-5 weeks and of warfarin 14 weeks. There were two minor episodes of recurr...

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Insulin therapy during pregnancy.

T congenital malformation remains the leading cause of mortality and serious morbidity in infants of mother with type 1 or type 2 diabetes, inspite of advancement in understanding pregnancy metabolism and treatment. Studies have established association between elevated maternal glucose during embryogenesis and high rates of spontaneous abortions and major malformations in newborn. Clinical tria...

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Metformin Therapy During Pregnancy

Type 2 diabetes and gestational diabetes mellitus (GDM) are closely related disorders characterized by increased insulin resistance. Metformin, a biguanide compound, exerts its clinical effect by both reducing hepatic glucose output and by increasing insulin sensitivity. This results in a decreased glucose level without an associated high risk of either hypoglycemia or weight gain. These charac...

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ژورنال

عنوان ژورنال: British Journal of Clinical Pharmacology

سال: 2020

ISSN: 0306-5251,1365-2125

DOI: 10.1111/bcp.14649